The axolotl limb blastema: cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods
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چکیده
منابع مشابه
Blastema formation and cell division during cockroach limb regeneration.
Recent models of pattern formation in insects have been derived largely from observations on regenerated cuticular patterns. Such models make assumptions about the behaviour of the underlying epidermal cells, their movement and patterns of cell division. The present study, designed to test these assumptions, looks at the patterns of wound healing and cell division after amputation at the trocha...
متن کاملDetermination of axial polarity in the urodele limb regeneration blastema.
The state of determination of the anterior-posterior, dorsal-ventral and proximal-distal axes of the undifferentiated limb regeneration blastema was evaluated by heterografting and autografting experiments in which these axes were reversed with respect to the limb stump. Species-specific size differences in skeletal elements were used as markers to trace the origin of regenerate tissues in the ...
متن کاملPositional Information Is Reprogrammed in Blastema Cells of the Regenerating Limb of the Axolotl (Ambystoma mexicanum)
The regenerating region of an amputated salamander limb, known as the blastema, has the amazing capacity to replace exactly the missing structures. By grafting cells from different stages and regions of blastemas induced to form on donor animals expressing Green Fluorescent Protein (GFP), to non-GFP host animals, we have determined that the cells from early stage blastemas, as well as cells at ...
متن کاملExpression of Hox A11 in the limb and the regeneration blastema of adult newt.
Homeoproteins are functionally involved in pattern formation of developing systems and are potentially good candidates to regulate positional information during limb regeneration in the newt. Here we report the molecular structure of Hox A11 and its pattern of expression during the regeneration of adult newt appendages. The transcriptional unit of the gene is composed of two exons separated by ...
متن کاملIdentification and expression of a regeneration-specific homeobox gene in the newt limb blastema.
Adult urodele amphibians are able to regenerate their limbs through the formation of a blastema, a growth zone of undifferentiated mesenchymal cells that arises locally at the plane of amputation. In an effort to define genes involved in pattern formation by the blastema, we isolated from a newt forelimb blastema library cDNA clones that identify a homeobox gene termed NvHbox 2. The amino acid ...
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ژورنال
عنوان ژورنال: Regeneration
سال: 2015
ISSN: 2052-4412
DOI: 10.1002/reg2.32